Thanks for your very well addressed questions Rob....

2008-11-08T10:05:00.000+01:00

Thanks for your very well addressed questions Rob. It is well known that different layers of tissue quench light signal by scattering and absorption. This has been always considered a limitation to the possibility of visualizing a probe in the most inner organs. Mayes and colleagues, conversely, exploited the scattering of fluorescent light emitted from tumor cells as it passes through blood vessels between the tumor cells and the detection source and... they detected, identified, and measured a «distinct spectral emission signature» of blood vessels present in fluorescent tumors. Theoretically, any single layer of cell contributes to the overall scatter, and you need to know its spectral signature to deconvolve it. Worth to note, spectral unmixing may be useful also to gain a 3D tomography of fluorescence or bioluminescence imaging. I will post new updates in the field.

Finally, I love people transforming disadvantages in advantages, as previously posted.

Almost as awesome as the 'brainbow' pics. What oth...

2008-11-07T20:46:00.000+01:00

Almost as awesome as the 'brainbow' pics. What other tissues change the emission by 10nm or more? Are there other applications of this?

Comments on Reportergene: Noninvasive vascular spectral unmixing

Thanks for your very well addressed questions Rob....

Almost as awesome as the 'brainbow' pics. What oth...