Bone morphogenetic proteins (BMP) are dimeric components initiating a number of distinct signaling cascades by binding to 2 sorts of transmembrane serine/threonine kinase receptors (BRI and BRII), and are thus […]
Inducible cAMP early repressor splice variants ICER I and IIgamma both repress transcription of c-fos and chromogranin A
Inducible cAMP early repressor (ICER) splice variants are generated upon activation of an alternate, intronic promoter inside the CREM gene. ICER is proposed to downregulate each its personal expression, and […]
When monocytes are stimulated with Lipopolysaccharide (LPS), they effectively produce cytokines like tumor necrosis issue (TNF). Upon secondary stimulation, this response is just minimal, and there may be little TNF […]
Extracellular vesicle-mediated transfer of genetic information between the hematopoietic system and the brain in response to inflammation.
Mechanisms behind how the immune system alerts to the mind in response to systemic irritation are usually not absolutely understood. Transgenic mice expressing Cre recombinase particularly within the hematopoietic lineage […]