Tolerance to lipopolysaccharide in human blood monocytes

Tolerance to lipopolysaccharide in human blood monocytes

When monocytes are stimulated with Lipopolysaccharide (LPS), they effectively produce cytokines like tumor necrosis issue (TNF). Upon secondary stimulation, this response is just minimal, and there may be little TNF mRNA transcription, mRNA accumulation, and protein manufacturing. Research with the monocytic cell line Mono Mac 6 have proven that in such tolerant cells the CD14 […]